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Subacute sclerosing panencephalitis after drug-induced immunosuppression.

A girl developed subacute sclerosing panencephalitis (SSPE). Eight years earlier she had had measles infection contracted shortly after cytotoxic treatment and radiotherapy for a spinal neuroblastoma. The case illustrates that typical SSPE, like immunosuppressive measles encephalopathy, can arise after drug-induced immunosuppression, and supports the view that these diseases probably represent opposite ends of a spectrum induced by measles virus infection in an individual with some form of immunological deficiency.

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				M. B.A. Oldstone, S. Dales, A. Tishon, H. Lewicki, and L. Martin A role for dual viral hits in causation of subacute sclerosing panencephalitis J. Exp. Med., November 7, 2005; 202(9): 1185 - 1190. [Abstract] [Full Text] [PDF]