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A 14-year-old boy had suffered from intermittent acute hepatic porphyria, myoclonic convulsions and mental retardation (Lennox-Gastaut syndrome). The porphyria was treated by stopping the administration of phenobarbitone and phenytoin. Sodium valproate at a dose of 70 mg/kg per day lessened the severity and frequency of convulsive crises.
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A S Winkler, T J Peters, and R D C Elwes Neuropsychiatric porphyria in patients with refractory epilepsy: report of three cases J. Neurol. Neurosurg. Psychiatry, March 1, 2005; 76(3): 380 - 383. [Abstract] [Full Text] [PDF] |
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