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Archives of Disease in Childhood 1981;56:342-344; doi:10.1136/adc.56.5.342
Copyright © 1981 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health
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Bronchodilator effects of clemastine, ipratropium, bromide, and salbutamol in preschool children with asthma.

R C Groggins, A D Milner, G M Stokes

The bronchodilator activity in nebulised salbutamol, ipratropium bromide, clemastine, and a placebo was studied in 14 asthmatic children aged between 3 and 5 years. Changes in lung function were monitored by measuring peak expiratory flow rate and total respiratory resistance using a modification of the forced oscillation technique. Ipratropium bromide produced a degree of bronchodilation similar to that of salbutamol, but the bronchodilatory activity of clemastine was not appreciably better than for the placebo.




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