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Does dexamethasone suppress the ACTH response in preterm babies?

Department of Paediatrics, University of Cambridge.

Tests of adrenal stimulation with adrenocorticotrophic hormone (ACTH) were performed before and after commencing dexamethasone treatment in 12 infants. All except one of the tests performed showed the expected twofold rise in serum cortisol, suggesting that in this group of premature babies dexamethasone did not suppress the adrenal response.