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The value of magnetic resonance spectroscopy in tumour imaging

¹ Academic Paediatrics and Child Health, University of Birmingham, UK
² Birmingham Children’s Hospital Foundation Trust, UK
³ Electrical, Electronic and Computer Engineering, University of Birmingham, UK
⁴ Academic Radiology, Nottingham University Hospitals, UK
⁵ Medical Physics and Imaging, University Hospital Birmingham Foundation Trust, UK
⁶ Royal Marsden Hospital Foundation Trust, UK
⁷ St George’s, University of London, UK
⁸ Nottingham University Hospitals, Nottingham, UK
⁹ Institute of Cancer Research, Sutton, UK
¹⁰ Great Ormond Street Hospital for Sick Children, London, UK
¹¹ Children’s Brain Tumour Research Centre, Nottingham University Hospitals, Nottingham, UK

Correspondence to:
Andrew Peet, Chair CCLG Functional Imaging Group, Academic Paediatrics and Child Health, Whittall Street, Birmingham B4 6NH, UK; acpeet@doctors.org.uk

Accepted for publication 23 April 2008

The first 150 words of the full text of this article appear below.

Magnetic resonance (MR) imaging has a key role in the management of many childhood tumours. There is increasing interest in extending these investigations to MR techniques that give information on tumour biology in vivo. Magnetic resonance spectroscopy (MRS) is one such method and it provides information on tissue biochemistry. Promising results have been obtained from many preclinical and clinical studies, leading to an expectation that MRS will play a valuable clinical role. However, the role of MRS is not yet well defined and there is a paucity of data from multi-centre clinical trials. In this article we concentrate on MRS in paediatric oncology and provide some general guidance on current applications and outline areas that need to be developed further.

MRS FUNDAMENTALS, DATA ACQUISITION AND ANALYSIS
Certain atomic nuclei (eg, ¹H, ³¹P and ¹³C) possess a magnetic moment and when placed in a strong magnetic field will resonate at a particular radiofrequency that subtly depends . . . [Full text of this article]